In vitro

Metabolism studies

• Study types
• - Metabolism/stability
• - Cyp450 isozyme mapping (reaction phenotyping)
• - Cyp450 isozyme induction and inhibition
• Test systems
  
  • - Microsomes
  • - Hepatocytes
  • - S9 fractions
  • - Cyp isozymes
• Interspecies comparison
• - Mouse
• - Rat
• - Rabbit
• - Pig
• - Dog
• - Monkey
• - Human

Freshly prepared hepatocytes are also available from rat, mouse, and dog. Bulk metabolite isolation and purification can be conducted upon request to obtain samples sufficient for further spectral investigation (i.e., 1-D and 2-D 1H and 13C NMR).

Protein binding studies
      Equilibrium dialysis, ultrafiltration, ultracentrifugation

Whole blood/plasma partitioning studies for most species