Monday, February 06, 2012

In vivo – ADME/PK

XenoBiotic Laboratories (XBL) maintains AAALAC-accredited, USDA-registered animal facilities. We are equipped to conduct in-life studies in rat (intact or bile/jugular vein cannulated), mouse and dog. XBL provides comprehensive radiolabel (3H or 14C) ADME study support across Non-clinical species. XBL has implemented the Debra LIMS system to guide ADME study conduct and analysis. Study types include:

  • Mass balance
  • Tissue distribution (necropsy or QWBA)
  • Metabolite radioprofiling and identification
  • Pharmacokinetic (single or multiple dose/formulation screening)
  • Cassette PK
  • Drug-drug interaction
  • Metabolism p450 enzyme induction
  • Bioavailability screening for various routes of administration