Higher Throughput ADME (HT-ADME) evaluation

Drug metabolism evaluation has become pivotal for new drug discovery and lead optimization. XenoBiotic Laboratories (XBL) staff has decades of experience enabling us to provide complete in vitro and in vivo metabolism data packages for new chemical entities (NCEs), as well as older products requiring updated information. XBL applies state-of-the-art instrumentation and methodology to provide a higher throughput ADME (HT-ADME) package that can accelerate drug discovery and lead optimization time, thereby conserving resources for future clinical development.

• Pilot screening studies - rapid PK for candidate selection
• Single compound and series of compounds on cassette dosing
• Bioanalytical method development for parent and metabolites
• PK parameter calculations