Sample analysis for PK and metabolite evaluation

One of XenoBiotic Laboratories' (XBL's) core capabilities is identifying and fully characterizing low level metabolites using state-of-the-art instrumentation and some of the most experienced staff in the industry.

XBL provides comprehensive sample analysis and metabolism study services

Sample analysis

• BA/BE/DDI clinical PK study sample analysis
• Plasma and urine sample assay of parent and key analytes in all phases of clinical and pre-clinical development using single or multiple analyte assay methods

Metabolite Monitoring and Quantitation

• Hot or cold samples from in-vitro, pre-clinical ADME, clinical AME or cold PK studies
• Metabolite radioprofiling, characterization, and structure identification utilizing specially designed LC/MS/MS systems, combined with on-line or off-line detectors such as PDA and RAM
• Radioprofiling with highly sensitive Topcount® and v.ARC™ Dynamic Flow radioactivity detectors
• Pharmacokinetic evaluation of active metabolites in all phases of clinical and pre-clinical development using LC/MS methods combined with semi-quantitative radioprofiling and NMR
• Bulk metabolite isolation and purification with structural elucidation (1-D and 2-D ¹H and ¹³C NMR)