Publications

"Comprehensive Investigation of Injection Time and Auto Gain Control on Ion Trap Instruments for the LC-MS Application of Metabolite Identification," Gu, Z., Bachalis, D., Ming, G., The 56^th ASMS Conference, Denver, CO, June 2008.

"A Rapid and High Sensitive LC-MS/MS Method for Quantitation of Budesonide in Human Plasma," Zhou,G., Zhou, D., Fang, X., and Wu, J., The 56^th ASMS Conference, Denver, CO, June 2008.

"Quantification of a Polypeptide Drug, Desirudin, in Human Plasma Using Electrospray LC-MS/MS with an Analog Polypeptide as Internal Standard," Wenzhong, L., Fang, X., and Wu, J., and Yu, T., The 56^th ASMS Conference, Denver, CO, June 2008.

"A High Sensitive LC-MS/MS Method for Quantitation of Formoterol in Human Plasma," Zhou, D., Wenzhong, L., Fang, X., and Wu, J., The 56^th ASMS Conference, Denver, CO, June 2008.

"A Sensitive LC-MS/MS Method for Quantitation of Ribavirin in Human Plasma," Fang, X., Zhou, W., Arriola, K., and Wu, J., The 56^th ASMS Conference, Denver, CO, June 2008.

"Preclinical Characterization of Intestinal Absorption and Metabolism of Promising Anti-Alzheimer's Dimer Bis(7)-tacrine," Zhang, L., Yu, H., Li, W., Cheung, M., Pang, Y., Gu, Z., Chan, K., Wang, Y., Zuof, Z., Fan Hang, Y., International Journal of Pharmaceutics, 357(1-2): 85–94, June 2008.

"Physicochemical Properties and the In Vivo AChE Inhibition of Two Potential Anti-Alzheimer Agents, Bis(12)-hupyridone and Bis(7)-tacrine," Yu, H., Kan, K.K.W., Ho, J.M.K., Li, W.M., Carlier, P.R., Pang, Y.P., Gu, Z., Chan, K.K.C., Wang, Y.T., and Han, Y.F., Journal of Pharmaceutical and Biomedical Analysis, 46(1): 75-81, January 2008.

"Ciclesonide Disposition and Metabolism I. Comparative In Vitro Metabolism of ¹⁴Cciclesonide in Hepatocytes from the Mouse, Rat, Rabbit, Dog and Human," Gu, Z., Zhao, X.G., Nave, R., Liu, D.D.W., Feng, H., Wu, J., Howell, S.R., and King, S., American Journal of Therapeutics, 14(3):280-290, May/June 2007.

"Automatic Generation of Extract ion Chromatogram for Mass Spectral Peaks with Specific Isotope Labeled Patterns," Ma, M., Gu, Z., Gu, M. and Wang, Y., The 55^th ASMS Conference, Indianapolis, IN, June 2007.

"Development of a High Performance Liquid Chromatography-Tandem Mass method for Determination of Bis(7)-tacrine, a Promising Anti-Alzheimer's Dimer, in Rat Blood," Yu, H., Kan, K.K.W., Ho, J.M.K., Li, W.M., Carlier, P.R., Pang, Y.P., Gu, Z., Chan, K.K.C., Wang, Y.T., and Han, Y.F., Journal of Pharmaceutical and Biomedical Analysis, 44(5): 1133-1188, May 2007.

"Mass Balance, Metabolism, and Excretion of Rambazole, a Novel Retinoic Acid Metabolism-Blocking Agent (RAMBA) in Mice, Rats, and Dogs," Gu, Z., Wu, D., Feng, H., and Barrett, D., The 14^th North American ISSX Meeting, Puerto Rico, October, 2006; Drug Met. Reviews, Vol. 38 (Suppl. 2.) 176, 2006.

"Sensitive and Rapid Method for the Determination of (R,R)-Formoterol and (S,S)-Formoterol in Human Plasma Using Chiral Liquid Chromatography-Tandem Mass Spectrometry," Gu, Z., Zhou, D., Huo, M., Hsu, R., and Maier, G., 2006 AAPS Annual Meeting, San Antonio, TX, October 2006.

"Ciclesonide Disposition and Metabolism II. Pharmacokinetics, Metabolism, and Excretion in the Mouse, Rat, and Dog," Guo, Z., Howell, S.R., and Gu, Z., American Journal of Therapeutics, 13(6):490-501, November/December 2006.

"Reduction of Nitriles to Amines in Positive Ion Electrospray Ionization Mass Spectrometry," Gu, Z., Ma, J., Zhao, X.G., and Wu, J., Rapid Communications in Mass Spectrometry, 20: 2969-2972, 2006.

"Determination of In Vivo Chiral Inversion of (R,R)-Formoterol to its Stereosiomers, (S,S)-Formoterol, (R,S)-Formoterol, and (S,R)-Formoterol, by Highly Sensitive and Specific LC/MS/MS Methods in Human Plasma," Gu, Z., Zhou, D., Huo, M., Hsu, R., Hsu, R., Maier, G., New England Drug Metabolism Discussion Group Summer Symposium, June, 2006.

"A New LC/MS/MS Method for Quantitation of Moxifloxacin in Human Plasma," Li, Y.X. and Zhou, D., The 54^th ASMS Conference, Seattle, WA, May 2006.

"A Highly Sensitive and Specific LC/MS/MS Method for Quantitation of Methotrexate and Its 7-Hydroxy Metabolite in Human Plasma," Li, Y.X. and Zhou, D., The 54^th ASMS Conference, Seattle, WA, May 2006.

"Automated and Parameter-Free Peak Integration for LC/MS/MS Quantitation," Gu, M., Zhou, D., Gu, Z.M., and Wang, Y., The 54^th ASMS Conference, Seattle, WA, May 2006.

"Reduction of Nitriles to Amines in Positive Ion Electrospray Ionization Mass Spectrometry," Ma, J. and Gu, Z.M., The 54^th ASMS Conference, Seattle, WA, May 2006.

"LC/MS Chiral Methods and Its Application in Bioanalysis," Zhou, D., Li, Y.X and Gu, Z.M., The 54^th ASMS Conference, Seattle, WA, May 2006.

"Accurate Mass Filtering of Ion Chromatograms for Metabolite Identification using a Unit Mass Resolution Liquid Chromatography/Mass Spectrometry System," Gu, M., Wang, Y., Zhao, X., and Gu, Z., Rapid Communications in Mass Spectrometry, 20: 764-770, 2006.

"Combining Profile Mode Mass Spectral Data Processing and Accurate Mass Filtering (AMF) for LC/MS Metabolite Applications," Zhao, X.G., Gu, Z., Gu, M., and Wang, Y., The 53^rd ASMS Conference, San Antonio, TX, May 2005.

"Accurate Mass Measurements on Unit Mass Resolution Mass Spectrometers," Gu, M., Wang, Y., Zhao, X.G., and Gu, Z., The 53^rd ASMS Conference, San Antonio, TX, May 2005.

"Differential Metabolism of Benzhydrolpiperidines in the Rat," ElNaggar, S.F., McLaughlin, T., Creekmore, R.W., Henrie, R., Wu, D., and Wu, J., ACS Agrochemicals Division meeting, San Diego, CA, March 2005.

"Pharmacokinetics, Metabolism, and Excretion of Ciclesonide after Intravenous and Oral Administration of ¹⁴CCiclesonide in Mice, Rats, Rabbits, and Dogs," Guo, Z., Howell, S., Gu, Z., Chen, K., Rohatagi, S., Cai, L., Wu, J., Stuhler, J., and King, P., 2004 AAPS Annual Meeting, Baltimore, MD, November 2004.

"In Vitro Metabolism of ¹⁴CCiclesonide in Hepatocytes from Mice, Rats, Rabbits, Dogs, and Humans," Gu, Z., Howell, S., Liu , D.D.W., Zhao, X., Feng, H., Wu, J., King, S.P., 2004 AAPS Annual Meeting, Baltimore, MD, November 2004.

"A Highly Sensitive and Specific LC/MS/MS Method (0.5 pg/mL) for Quantitation of (R/R)/(S,S)Formoterol and (R,S)/(S,R)Formoterol in Human Plasma and Urine," Zhou, D., Huo, M., Caruso, J., Zhou, G., Potenza, L., Hsu, R.S.H., and Li, Y., The 52^nd ASMS Conference, Nashville, TN, May 2004.

"Loss of Hydroxyl Radical (•OH) in CID MS/MS for Identification of Oxidative Drug Metabolites," Zhao, X., Ma, J., Feng, H., and Gu, Z., The 52^nd ASMS Conference, Nashville, TN, May 2004.

"Metabolism and Pharmacokinetics of Carfentrazone-Ethyl in the Rat," ElNaggar, S.F., McCarty, J.D., Froelich, L.W., Wu, D., and Chemidlin, J., ACS Agrochemicals Division meeting, Anaheim, CA, March-April 2004.

"Metabolism and Disposition of F7967 in the Rat," ElNaggar, S.F., Zhang, J. Creekmore, R.W., Letinski, D., Curry, S.J., Goudar, J., Wang, G., Wu, D., and Gu, Z., ACS Agrochemicals Division meeting, Anaheim, CA, March-April 2004.

"Tissue Distribution, Metabolism, and Residue Depletion Study in Atlantic Salmon Following Oral Administration of [³H]Emamectin Benzoate," Kim-Kang, H., Bova, A., Crouch, L.S., Wislocki, P.G., Robinson, R.A., and Wu, J., J. Agric. Food Chem., 52(7): 2108-2118, 2004.

"Determination of Flunixin in Edible Bovine Tissues Using Liquid Chromatography Coupled with Tandem Mass Spectrometry," Boner, P.L., Liu, D.D.W., Feely, W.F., Robinson, R.A., Wu, J., J. Agric. Food Chem., 51(26): 7555-7559, 2003.

"Mass Balance Study of ¹⁴C-Nebivolol in Humans with Different CYP2D6 Genotypes," Chien, C., Liang, D., Gu, Z., Robinson, R.A., Wu, J., and Huang, M., 2003 AAPS Annual Meeting, Salt Lake City, UT, October 27-30, 2003.

"Determination of (R,R)-Formoterol Inversion Products in Human Plasma and Urine By Chiral and Achiral-LC/MS/MS," Gu, Z., Zhao, X., Maier, G., Hsu, R.H.S., 2003 AAPS Annual Meeting, Salt Lake City, UT, October 27-30, 2003.

"Metabolism Study of ¹⁴C-Nebivolol in Humans with Different CYP2D6 Genotypes," Gu, Z., Robinson, R., Cai, L., Wu, J., Duncan, J., Owens, W., Liang, D., Huang, M., O'Donnell, J., 2003 AAPS Annual Meeting, Salt Lake City, UT, October 2003.

"Tissue Distribution, Metabolism, and Residue Depletion Study in Atlantic Salmon Following Oral Administration of ³H-Emamectin Benzoate," Kim-Kang, H., The 12th North American ISSX Meeting, October 12-16, 2003, Providence, RI; Drug Met. Reviews, Vol. 35 (Suppl. 2.) 222, 2003.

"Determination and Confirmation of 5-Hydroxyflunixin in Raw Bovine Milk Using Liquid Chromatography Tandem Mass Spectrometry," Boner, P., Liu, D.D.W., Feely, W.F., Wisocky, M.J., and Wu, J., J. Agric. Food Chem., 51: 3753-3759, 2003.

"Flunixin Residues in Milk after Intravenous Treatment of Dairy Cattle with ¹⁴CFlunixin," Feely, W.F., Chester-Yansen, C., Thompson, K., Campbell, J.W., Boner, P.L., Liu, D.D.W., and Crouch, L.S., J. Agric. Food Chem., 50(25): 7308-7313, 2003.

"Simultaneous Determination of the Enantiomers of Ketorolac As Well As XBL011003 in Human Plasma with LC/MS," Li, Y., Schmidt, E., Huo, M., Zhou, G., Wu, J., and Zhou, D., The 51^st ASMS Conference, Montreal/Quebec, Canada, June 2003.

"A Highly Sensitive and Specific LC/MS/MS Method (3 pg/mL) for Quantitation of Fluticasone Propionate in Human Plasma," Zhou, D., Zhou, G., Scotto, C., Caruso, J., Wu, J., and Li, Y., The 51^st ASMS Conference, Montreal/Quebec, Canada, June 2003.

"Biotransformation of [¹⁴C] BMS275183 in Bile-Duct Cannulated (BDC) Rats," Comezoglu, N., Kim-Kang, H., Ogan, M., and Everett, D., The 11th North American ISSX Meeting, October 2002, Orlando, FL; Drug Met. Reviews, Vol. 34 (Suppl. 1.) 65, 2002.

"Metabolism of [¹⁴C] BMS275183 in Mouse, Rat, Dog, Monkey and Human Liver Microsomes," Kim-Kang, H., Comezoglu, N., Ogan, M., and Everett, D., The 11th North American ISSX Meeting, October 2002, Orlando, FL; Drug Met. Reviews, Vol. 34 (Suppl. 1.) 65, 2002.

"Simultaneous Quantitation of 9-Nitrocamptothecin, an Anticancer Agent, and Its Metabolite, 9Aminocamptothecin, by LC/MS/MS in Rat, Rabbit, and Human Plasma and Human Urine," Z. Gu, X. Zhao, D. Zhou, M. Huo, H. Sands, and J. Wu, The 50th ASMS Conference, Orlando, FL, June 2002.

"A New Liquid Chromatography-Tandem Mass Spectrometry Method (0.1-1,000 ng/mL) for Quantitation of Paclitaxel in Human and Rat Plasma," D. Zhou, G. Zhou, M. Huo, J. Wu, and Z. Gu, The 50th ASMS Conference, Orlando, FL, June 2002.

"Formation of Metal Adduct Solvent Ions or Ion Clusters and their Influence on LC/MS Analysis," Z. Gu, D. Zhou, X. Zhao, and J. Wu, The 50th ASMS Conference, Orlando, FL, June 2002.

"Enhancement of SCH 211803 ESI/LCMS Metabolite Identification in Mouse and Rat Bile by the Removal of Matrix-Induced Ion Supression," Iannucci, R.M., Achanfuo-Yeboah, J., Kaczynski, E.J., Ramaiya, A., Chowdhurry, S.K., Stauber, K.L., Gu, Z., Alton, K.B., and Patrick, J.E., The 50th ASMS Conference, Orlando, FL, June 2002.

"Studies on rosiglitazone maleate intragastric floating sustainedreleased tablet," Feng, H., Wang, Z., and Chen, D., Journal of China Pharmaceutical University, 33(3): 196-199, 2002.

"A review on interaction of Compatibility of medicine and traditional Chinese medicine," Feng, H. and Wang, Z., Chinese Journal of Experimental Traditional Medical Formulae, 8(2): 53-55, 2002.

"Determination of Emamectin Residues in the Tissues of Atlantic Salmon (Salmo salar L.) Using HPLC with Fluorescence Detection," H. Kim-Kang, L.S. Crouch, A. Bova, R.A. Robinson, and J. Wu, J. Agric. and Food Chem., 49(11): 5294-5302, 2001.

"LC/MS/MS Quantification of 9-Nitrocamptothecin and 9-Aminocamptothecin in Dog Plasma Using Atmospheric Pressure Chemical Ionization or Electrospray Ionization Methods," O. Timofeev, H. Usansky, Z. Gu, I. Segarra, H. Sands, P.J. Sinko, and T.J. Cook, 2001 AAPS Annual Meeting, Denver, CO, October 2001.

"Biotransformation of [¹⁴C] BMS-184476 in Bile-Duct Cannulated (BDC) Rats," N. Comezoglu, D.W. Everett, S. Lan, Z. Gu, S. Bonacorsi, M. Ogan, and K.J. Kripalani, 2001 AAPS Annual Meeting, Denver, CO, October 2001.

"Keys to Successful Outsourcing Choices," N.J. Lewis, Contract Pharma, Vol. 2, No. 1, 38-43, January/February 2000.

"Pharmacokinetics and Mass Balance of Porfiromycin in the Rat and Dog," J. Mao, W.S. Lang, S. Barrows, B. Almassian, and J. Chemidlin, 1999 AAPS Annual Meeting, New Orleans, LA, November 1999, Abstract No. 1087.

"The Disposition of a Single Dose of ¹⁴C OPC-41061 in Healthy Male Volunteers," B.K. Tammara, K. Sekar, and S.L. Bramer, 1999 AAPS Annual Meeting, New Orleans, LA, November 1999, Abstract No. 2025.

"Quantitative Evaluation of Annonaceous Acetogenins in Monthly Samples of Paw Paw (Asimina triloba) Twigs by Liquid Chromatography/Electrospray Ionization/Tandem Mass Spectrometry," Z. Gu, D. Zhou, N.J. Lewis, J. Wu, H.A. Johnson, J.L. McLaughlin, and J. Gordon, Phytochemical Analysis, 10, 32-38, 1999.

"Chemical Defense in the Zebra Swallowtail Butterfly, Eurytides marcellus, Involving Annonaceous Acetogenins," J.M. Martin, S.R. Madigosky, Z. Gu, D. Zhou, J. Wu, and J.L. McLaughlin, J. Nat. Prod, 62, 2-4, 1999.

"Aged Soil Column Leaching of Emamectin Benzoate (MAB1a)," J.S. O'Grodnick, P.G. Wislocki, J.L. Reynolds, M. Wisocky, and R.A. Robinson, J. Agric. Food Chem., 46, 2044-2048, 1998.

"A Sensitive and Specific Chiral LC-MS/MS Method for Quantitative Analysis of Low Levels of Enantiomers of OPC-29030 in Human Plasma and Urine," J. Wu, P. Tata, Z. Gu, and S. Bramer, 1998 AAPS Annual Meeting, San Francisco, CA, November 1998.

"Development and Validation of a Determinative Method for the Analysis of Flunixin in Bovine Liver," R.A. Robinson, D.D.W. Liu, M. Wisocky, A.M. Bova, and R.P. Clement, 1998 AAPS Annual Meeting, San Francisco, CA, November 1998.

"Development and Validation of a Method for the Quantitative Determination of OPC-41061 and its Metabolites by LC-MS/MS," K. Sekar, Z. Gu, P.N.V. Tata, D. Zhou, and S. Bramer, 1998 AAPS Annual Meeting, San Francisco, CA, November 1998.

"A Sensitive and Specific LC-MS/MS Method for the Analysis of OPC-29030 and Ten Metabolites in Human Plasma and Urine," Z. Gu, P.N.V. Tata, D. Zhou, R.R. Abbas, J. Wu, N.J. Lewis, and S. Bramer, 1998 AAPS Annual Meeting, San Francisco, CA, November 1998.

"Fate of [¹⁴C]Diphenylamine in Stored Apples," H. Kim-Kang, R.A. Robinson, and J. Wu, J. Agric. Food Chem., 46, pp. 707-717, 1998.

"Reversal effect of Ys-96, a bisbenzylisoquinoline, on Adriamycine or Vincristine Resistance in human cancer cellsin Vitro," Ye, Z., Sun, A., Li, C., Xue, B., Wang, Z., Tong, Y., Feng, H., et. al., China Journal of Chinese Materia Medica, 23(7): 427-428, 1998.

"High-Throughput Pharmacokinetics in Support of Drug Discovery: Pharmacokinetic Testing of Pools of NSubstituted Glycines in Mice," C.M. Dietz, H. Luo, Z-P. Luo, Z. Gu, J. Wu, D. Zhou, R.A. Braeckman, and J.A., Gibbons, Pharmaceutical Research, 14, Abstract No. 2566, p. S-397, 1997.

"Absolute Stereochemistry of DPI-3290W93: A New Multichiral Opioid Analgesic with Reduced Respiratory Depression," D.D.W. Liu, S.N. Comezoglu, K-J. Chang, H.O. Pettit, and N.J. Lewis, Pharmaceutical Research, 14, Abstract No. 4260, p. S-694, 1997.

"On-line Coupling of In Vivo Rat Biliary Elimination and Pharmacokinetics with Liquid Chromatograhy/Mass Spectrometry (LC/MS)," J. Wu, Z. Gu, J. Chemidlin, Z. Liang, D. Wu, N.J. Lewis, S. Smith, and D.A. Hawkins, American Chemical Society, 213^th National Meeting, April 13-17, 1997.

"Development of HPLC Methods for Assessment of Epimeric Impurities in DP-3290W93: A New Opioid Analgesic with Three Chiral Centers," D.D.W. Liu, S.N. Comezoglu; A. Hussain, K-J. Chang, H.O. Pettit, J.Wu, and N.J. Lewis, Pharmaceutical Research, 14, Abstract No. 4169, p. S-686, 1997.

"Screening for Annonaceous Acetogenins in Bioactive Plant Extracts by Liquid Chromatography/Mass Spectrometry," Z. Gu, D. Zhou, J. Wu, G. Shi, L. Zeng, and J.L. McLaughlin, J. Natural Products, 60, pp. 242-248, 1997.

"Isolation of New Bioactive Annonaceous Acetogenins from Rolling mucosa Guided by Liquid Chromatography/ Mass Spectrometry," Z. Gu, D. Zhou, N.J. Lewis, J. Wu, G. Shi, and J.L. McLaughlin, Bioorganic and Medicinal Chemistry, 5, pp. 1911-1916, 1997.

"Metabolism of [¹⁴C]Cypermethrin in Sugar Beet," S.N. Comezoglu, Z. Liang, V.T. Ly, J. Wu, R.A. Robinson, M. George, J.H. Finley, and L.W. Froelich, American Chemical Society, 212^th National Meeting, August 1996.

"Degradation of [¹⁴C]Propargite in Soil," S.N. Comezoglu, V.T. Ly, J. Wu, W.H. Harned, D.G.Dzialo, and C.K.White, American Chemical Society, 211^th National Meeting, March 1996.

"On-line Coupling on In Vivo Rat Biliary Elimination and Pharmacokinetics with Liquid Chromatography/Mass Spectrometry," Z. Liang, D. Wu, J. Accatatta (Chemidlin), and J. Wu, Mid-Atlantic Pesticide Discussion Group, Spring Meeting, 1996.

"Metabolic Fate of Oxyfluorfen in Laying Hens," H. Kim-Kang, J.P. Hogya, J.D. Smalley, R.A. Robinson, J. Wu, Q. Zhang, P. Reibach, and B.P. Chong, American Chemical Society, 207^th National Meeting, March 1994.

"A Comparison of Radioactivity Detection Methods Available for Thin-Layer Chromatography," D. Hawkins, J. Wu, J. Ryan, and R. Weintraub, Mid-Atlantic Pesticide Metabolism Discussion Group, February 1993.

"The Aqueous Photolysis of ¹⁴C-Oxyfluorfen Following Irradiation with a Xenon Light Source," P.H. Reibach, D.E. Karr, J.L. Reynolds, and J. Wu, American Chemical Society, 204^th National Meeting, August 1992.

"Metabolic Fate of Mevinphos in the Lactating Goat," J. Wu, D.D.W. Liu, R.A. Robinson, E.M. Craine, and D.I. Wang, American Chemical Society, 204^th National Meeting, August 1992.

"Ametryn in Rats, Lactating Goats, and Laying Hens-Metabolic Fate," J. Wu, D.D.W. Liu, R.A. Robinson, W. Itterly, and T.M. Capps, Chapter 12, pp. 168-189, Xenobiotics and Food Producing Animals-Metabolism and Residues, American Chemical Society Symposium Series 503, 1992.

"Maduramicin: Characterization of ¹⁴C-Derived Residues in Turkey Excreta," S.J. Stout, J. Wu, A.R. daCunha, K.G. King, and A-H-Lee, J Agric. Food Chem., 39, p.386, 1991.

"Metabolic Fate of Ametryn in Rats, Lactating Goats and Laying Hens," J. Wu, D.D.W. Liu, and R.A. Robinson, American Chemical Society, 202^nd National Meeting, August 1991.

"The Metabolism of Pentachloronitrobenzene (PCNB) in Mature Field Grown Peanuts, Cabbage, and Potatoes" J.E. Cassidy, D. Liu, and J. Wu, Gordon Conference, 1990.