Posters

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Disposition, Metabolism and Mass Balance of [14C] Apremilast, a Novel PDE4 Inhibitor, Following Oral Administration, Presented at the Society of Investigative Dermatology, Phoenix, AZ, May 7, 2011.

Investigation of SEP-227900 metabolites in Humans from the First-in-Man Study Samples by LC-MS and NMR, Presented at the 2011 AAPS Annual Meeting, Washington, DC, October 2011.

Identification and Determination of the Percent AUC of Five Metabolites of a Tetrahydropyran-containing Drug, Co-eluting as a Broad Peak due to the Presence of Metabolites Undergoing Conformational Change during HPLC Radiochromatography, Presented at the 17th Annual North American Regional ISSX Meeting, Atlanta, GA, October 2011.

Investigation of Incurred Sample Reanalysis Failure in Sample Analysis for Human Urine P-Aminohippuric Acid and Metformin, Presented at the 12th Annual Land O' Lakes Bioanalytical Conference, Madison, WI, July 2011.

An LC-MS/MS Method for Simultaneously Determining Formoterol and Budesonide in Human Plasma with Dual HPLC System, Presented at the 59th ASMS Conference, Denver, CO, June 2011.

Validation of A Surrogate Derivative LC/MS/MS Method for the Determination of Glucose in Human Plasma with [¹³C₆] D-Glucose as a Tracer, Presented at the 59^th ASMS Conference, Denver, CO, June 2011.

Comparative in vitro Metabolism of Benzyl Amine Containing Test Drug Using Human, Rat, and Dog Plasma – Investigation of Amine Oxidase Involvement in Drug Metabolism, Presented at the 9^th International ISSX Meeting, Istanbul, Turkey, September 2010.

Application of ¹⁹F NMR to Mass Balance Studies, Presented at the 9^th International ISSX Meeting, Istanbul, Turkey, September 2010.

Mass Defect Filtering: a New Tool to Expedite Screening, Dereplication and Identification of Natural Products, Presented at The 58^th ASMS Conference, Salt Lake City, UT, May 2010.

A Selective and Sensitive LC-MS/MS Method for the Determination of Beclomethasone Dipropionate and Beclomethasone-17-Propionate in Human Plasma, Presented at The 58th ASMS Conference, Salt Lake City, UT, May 2010.

Accurate Measurement of Biopolymer Molecular Weight with Orbitrap Mass Spectrometer, Presented at The 58th ASMS Conference, Salt Lake City, UT, May 2010.

Metabolism and Excretion of PRT060128, a New Competitive, Reversible P2Y12 Inhibitor, in Healthy Human Subjects, Presented at the 2008 AAPS Annual Meeting, Atlanta, GA, November 2008.

Structural Determination of By-Products Obtained in Acetylation of Cysteine and Cysteine-Conjugated Metabolites by LTQ-Orbitrap XL � Leading to the Establishment of an Alternative Esterification and Amidation Method, Presented at The 57th ASMS Conference, Philadelphia, PA, June 2009.

A Sensitive LC-MS/MS Method for the Determination of KX2-391 in Human Plasma, Presented at The 57th ASMS Conference, Philadelphia, PA, June 2009.

A Rapid LC-MS/MS Method for the Determination of Telbivudine in Human Plasma, The 57th ASMS Conference, Philadelphia, PA, June 2009.

Quantification of a Polypeptide Drug, Desirudin, in Human PlasmaUsing Electrospray LC-MS/MS with an Analog Polypeptide as Internal Standard, Presented at The 56th ASMS Conference, Denver, CO, June 2008.

Comprehensive Investigation of Injection Time and Auto Gain Control on Ion Trap Instruments for LC/MS Application of Metabolite Identification, Presented at The 56th ASMS Conference, Denver, CO, June 2008.

A Rapid and High Sensitive LC-MS/MS Method for Quantitation of Budesonide in Human Plasma, Presented at The 56th ASMS Conference, Denver, CO, June 2008.

A Sensitive LC-MS/MS Method for Quantitation of Ribavirin in Human Plasma, Presented at The 56th ASMS Conference, Denver, CO, June 2008.

A High Sensitive LC-MS/MS Method for Quantitation of Formoterol in Human Plasma, Presented at The 56th ASMS Conference, Denver, CO, June 2008.

Automatic Generation of Extract ion Chromatogram for Mass Spectral Peaks with Specific Isotope Labeled Patterns, Presented at The 55th ASMS Conference, Indianapolis, IN, June 2007.

Mass Balance, Metabolism, and Excretion of Rambazole, a Novel Retinoic Acid Metabolism-Blocking Agent (RAMBA) in Mice, Rats, and Dogs, Presented at The 14^th North American ISSX Meeting, Puerto Rico, October, 2006.

Sensitive and Rapid Method for the Determination of (R,R)-Formoterol and (S,S)-Formoterol in Human Plasma Using Chiral Liquid Chromatography-Tandem Mass Spectrometry, Presented at the 2006 AAPS Annual Meeting, San Antonio, TX, October 2006.

Determination of In Vivo Chiral Inversion of (R,R)-Formoterol to its Stereosiomers, (S,S)-Formoterol, (R,S)-Formoterol, and (S,R)-Formoterol, by Highly Sensitive and Specific LC/MS/MS Methods in Human Plasma Presented at the G., New England Drug Metabolism Discussion Group Summer Symposium, June, 2006.

Automated and Parameter-Free Peak Integration for LC/MS/MS Quantitation, Gu, M., Zhou, D., Gu, Z.M., and Wang, Y., presented at the 54^th ASMS Conference, Seattle, WA, May 2006.

 LC/MS Chiral Methods and Its Application in Bioanalysis, Presented at The 54^thASMS Conference, Seattle, WA, May 2006.

 Reduction of nitriles to amines in positive ion electrospray ionization mass spectrometry, Presented in Rapid Communications in Mass Spectrometry, 20: 2969-2972, 2006.

A Highly Sensitive and Specific LC/MS/MS Method for Quantitation of Methotrexate and Its 7-Hydroxy Metabolite in Human Plasma, Presented at The 54^th ASMS Conference, Seattle, WA, May 2006.

A New LC/MS/MS Method for Quantitation of Moxifloxacin in Human Plasma, Presented at the The 54^th ASMS Conference, Seattle, WA, May 2006.

In Vitro Metabolism of ¹⁴C-Ciclesonide in Hepatocytes from Mice, Rats, Rabbits, Dogs and Humans
Presented at the American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition, November, 2004, Baltimore MD.

Pharmacokinetics, Metabolism, and Excretion of Ciclesonide after Intravenous and Oral Administration of ¹⁴C-Ciclesonide in Mice, Rats, Rabbits and Dogs
Presented at the American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition, November, 2004, Baltimore, MD.

Loss of Hydroxyl Radical (�OH) in CAD MD/MS for Identification of Oxidized Drug Metabolites
Presented at the American Society for Mass Spectrometry (ASMS) Conference on Mass Spectrometry, May, 2004, Nashville TN.

A Highly Sensitive and Specific LC/MS/MS Method (0.5 pg/mL) for Quantitation of (R,R)/(S,S)-Formoterol and (R,S)/(S,R)-Formoterol in Human Plasma and Urine
Presented at the American Society for Mass Spectrometry (ASMS) Conference on Mass Spectrometry, May, 2004, Nashville TN.

Tissue Distribution, Metabolism and Residue Depletion Study in Atlantic Salmon Following Oral Administration of 3H-SCH 58854
Presented at the International Society for the Study of XenoBiotics (ISSX) 12^th North American Meeting, October, 2003, Providence, RI.

Determination of (R,R)-Formoterol Inversion Products in Human Plasma and Urine By Chiral and Achiral-LC/MS/MS
Presented at the American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition, October, 2003, Salt Lake City, UT.

Mass Balance Study of ¹⁴C-Nebivolol in Humans with Different CYP2D6 Genotypes
Presented at the American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition, October, 2003, Salt Lake City, UT.

Metabolism Study of ¹⁴C-Nebivolol in Humans with Different CYP2D6 Genotypes
Presented at the American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition, October, 2003, Salt Lake City, UT.

A Highly Sensitive and Specific LC/MS/MS Method (3 pg/mL) for Quantitation of Fluticasone Propionate in Human Plasma
Presented at the American Society for Mass Spectrometry (ASMS) 51^st Conference on Mass Spectrometry, June, 2003, Montreal, QC.

Simultaneous Determination of the Enantiomers of Ketorolac as well as XBL011003 in Human Plasma with LC/MS
Presented at the American Society for Mass Spectrometry (ASMS) 51^st Conference on Mass Spectrometry, June, 2003, Montreal, QC.

Simultaneous Quantitation of 9-Nitrocamptothecin an Anticancer Agent, and its Metabolite, 9-Aminocamptothecin by LC/MS/MS in Rat, Rabbit, and Human Plasma and Human Urine
Presented at the American Society for Mass Spectrometry (ASMS) 51^st Conference on Mass Spectrometry, June, 2002, Orlando, FL.

A New Liquid Chromatography-Tandem Mass Spectrometry Method (0.1-1,000 ng/mL) for Quantitation of Paclitaxel in Human and Rat Plasma
Presented at the American Society for Mass Spectrometry (ASMS) Conference on Mass Spectrometry, June, 2002, Orlando, FL.

Formation of Metal Adduct Solvent Ions or Ion Clusters and the Influence on LC/MS Analysis
Presented at the American Society for Mass Spectrometry (ASMS) Conference on Mass Spectrometry, June, 2002, Orlando, FL